• Magnetic Resonance Imaging
• Chemical Exchange Saturation Transfer
• Medical Image Analysis
• Artificial Intelligence

Journal Papers

• Huang J, van Zijl PCM, Han X, Dong CM, Cheng GWY, Tse K-H, Knutsson L, Chen L, Lai JHC, Wu EX, Xu J, Chan KWY. Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI. Science Advances, 2020, 6(20): eaba3884.
• Chen L, Schär M, Chan KWY, Huang J, Wei Z, Lu H, Qin Q, Weiss RG, van Zijl PCM, Xu J. In vivo imaging of phosphocreatine with artificial neural networks. Nature Communications, 2020, 11(1): 1-10.
• Huang J, Lai JHC, Tse K-H, Cheng GWY, Liu Y, Chen Z, Han X, Chen L, Xu J, Chan KWY. Deep neural network based CEST and AREX processing: Application in imaging a model of Alzheimer’s disease at 3 T. Magnetic Resonance in Medicine, 2022, 87(3): 1529-1545. (Editor Pick & MRM Highlight)
• Huang J, Lai JHC, Han X, Chen Z, Xiao P, Liu Y, Chen L, Xu J, Chan KWY. Sensitivity schemes for dynamic glucose-enhanced magnetic resonance imaging to detect glucose uptake and clearance in mouse brain at 3 T. NMR in Biomedicine, 2022, 35(3): e4640. (Cover Article)
• Huang J, Chen Z, Park SW, Lai JHC, Chan KWY. Molecular Imaging of Brain Tumors and Drug Delivery Using CEST MRI: Promises and Challenges. Pharmaceutics, 2022, 14(2): 451.
• Huang J, Xu J, Lai JHC, Chen Z, Lee CY, Mak HKF, Chan KH, Chan KWY. Relayed nuclear Overhauser effect weighted (rNOEw) imaging identifies multiple sclerosis. NeuroImage: Clinical, 2021, 32: 102867.
• Huang J, Han X, Chen L, Xu X, Xu J, Chan KWY. Relayed nuclear Overhauser enhancement imaging with magnetization transfer contrast suppression at 3 T. Magnetic Resonance in Medicine, 2021, 85(1): 254-267.
• Huang J, Chen L, Chan KWY, Cai C, Cai S, Chen Z. Super-resolved water/fat image reconstruction based on single-shot spatiotemporally encoded MRI. Journal of Magnetic Resonance, 2020, 314: 106736.
• Huang J, Zhang M, Lu J, Cai C, Chen L, Cai S. A fast chemical exchange saturation transfer imaging scheme based on single‐shot spatiotemporal encoding. Magnetic Resonance in Medicine, 2017, 77(5): 1786-1796.
• Law LH#, Huang J#, Xiao P, Liu Y, Chen Z, Lai JHC, Han X, Cheng GWY, Tse KH, Chan KWY. Multiple CEST contrast imaging of nose-to-brain drug delivery using iohexol liposomes at 3T MRI. Journal of Controlled Release, 2023, 354, 208-220. (#Contributed equally)
• Chen Z#, Huang J#, Lai JHC, Tse KH, Xu J, Chan KWY. Chemical exchange saturation transfer (CEST) MRI detects myelin changes in cuprizone mouse model at 3T. NMR in Biomedicine, 2023, 10.1002/nbm.4937.
• Wang RPH, Huang J, Chan KWY, Leung WK, Goto T, Ho YS, & Chang RCC. IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer’s disease. Journal of Neuroinflammation, 2023, 20(1): 1-30.
• Lai J H C, Liu J, Yang T, Huang J, Liu Y, Chen Z, Lee Y, Leung GKK, Chan KWY. Chemical exchange saturation transfer magnetic resonance imaging for longitudinal assessment of intracerebral hemorrhage and deferoxamine treatment at 3T in a mouse model. Stroke, 2023, 54(1): 255-264.
• Xiao P, Huang J, Han X, Cheu JWS, Liu Y, Law LH, Lai JHC, Li J, Park SW, Wong CCL, Lam RHW, Chan KWY. Monitor Tumor pHe and Response Longitudinally during Treatment Using CEST MRI-Detectable Alginate Microbeads. ACS Applied Materials & Interfaces, 2022, 14, 49, 54401–54410.
• Chen X, Wang W, Huang J, Wu J, Chen L, Cai C, Cai S, Chen Z. Ultrafast water–fat separation using deep learning–based single-shot MRI. Magnetic Resonance in Medicine, 2022, 87(6): 2811-2825.
• Han Z, Chen C, Xu X, Bai R, Staedtke V, Huang J, Chan KWY, Xu J, Kamson DO, Wen Z, Knutsson L, van Zijl PCM, Liu G. Dynamic contrast-enhanced CEST MRI using a low molecular weight dextran. NMR in Biomedcine, 2022, 35(3): e4649.
• Sui R, Chen L, Li Y, Huang J, Chan KWY, Xu X, van Zijl PCM, Xu J. Whole‐brain amide CEST imaging at 3T with a steady‐state radial MRI acquisition. Magnetic Resonance in Medicine, 2021, 86(2): 893-906.
• Chen L, Wei Z, Chan KWY, Li Y, Suchal K, Bi S, Huang J, Xu X, Wong PC, Lu H, van Zijl PCM, Li T, Xu J. D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI. Journal of Cerebral Blood Flow & Metabolism, 2021, 41(5): 1013-1025.
• Han X, Lai JHC, Huang J, Park SW, Liu Y, Chan KWY. Imaging self-healing hydrogels and chemotherapeutics using CEST MRI at 3 T. ACS Applied Bio Materials, 2021, 4(7): 5605-5616.
• Han X, Huang J, To AK, Lai JHC, Xiao P, Wu EX, Xu J, Chan KWY. CEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T. Theranostics, 2020, 10(5): 2215.

Conference Proceedings

• Huang J, CEST: Journey to the Clinic. ISMRM & SMRT, Toronto, Canada, 2023, Educational Talk, No. E8354. (Invited Speaker)

• Huang J, Chen Z, van Zijl PCM, Law LH, Pemmasani Prabakaran RS, Park SW, Xu J, Chan KWY. Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia. ISMRM-ESMRMB & ISMRT, London, UK, 2022, Oral Session, No.3836.

• Huang J, Lai JHC, Han X, Chen Z, Liu Y, Xiao P, Chen L, Xu J, Chan KWY. Sensitive imaging schemes for dynamic glucose enhanced (DGE) MRI to detect glucose uptake and clearance in mouse brain at 3T. ISMRM & SMRT, 2021, Oral Session, No.0433. (Summa Cum Laude)

• Huang J, Xu J, Lai JHC, Mak HKF, Chan KH, Chan KWY. Relayed nuclear Overhauser effect (rNOE) imaging identifies multiple sclerosis: an initial human study. ISMRM & SMRT, 2021, Oral Session, No.0492.

• Huang J, Lai JHC, Tse K-H, Cheng GWY, Han X, Liu Y, Chen Z, Chen L, Xu J, Chan KWY. CEST and AREX data processing based on deep neural network: application to image Alzheimer’s disease at 3T. ISMRM & SMRT, 2021, Digital Poster, No.3707.

• Huang J, Han X, Dong CM, Cheng GWY, Tse K-H, Chen L, Lai JHC, Wu EX, van Zijl PCM, Xu J, Chan KWY. Dynamic glucose enhanced (DGE) MRI at 3T detects alterations in glucose uptake and clearance in young and old Alzheimer’s mice. ISMRM & SMRT, 2020, Oral Session, No.0212. (Magna Cum Laude)

• Huang J, Han X, Chen L, Xu X, van Zijl PCM, Xu J, Chan KWY. Magnetization transfer contrast (MTC) suppressed relayed nuclear Overhauser enhancement (rNOE) imaging at 3 T. ISMRM & SMRT, 2020, Digital Poster, No.3141.

• Huang J, Xu J, Dong CM, Chen L, Han X, Wu EX, Van Zijl PCM, Chan KWY. Dynamic glucoCEST MRI detects regional changes in cerebral glucose uptake in Alzheimer’s disease at 3T. ISMRM 27th Annual Meeting & Exhibition, Montréal, Canada, 2019, Oral Session, No.0626.